Anaplastic Large Cell Lymphoma ALK-Negative: About a Rare Pediatric Case Report

Louachama Ouidad1, *, Elbaz Meriem2, El Houdzi Jamila1
1 Department of Pediatric Hematology and oncology, University Hospital Mohammed VI, Marrakesh separate by comma, Morocco
2 Department of Pediatric Hematology and oncology, Faculty of Medicine, University Cadi Ayad, Marrakesh, Morocco

© 2020 Ouidad et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: ( This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Pediatric Hematology and oncology, University Hospital Mohammed VI, Marrakesh, Morocco, E-mail:



Anaplastic Large Cell Lymphomas (ALCL) are rare in childhood but clinically aggressive. The contemporary World Health Organization (WHO) classification of hematologic malignancies recognizes two distinct subtypes of systemic ALCL: Anaplastic Lymphoma Kinase (ALK)-negative, and ALK-positive.

Case report:

We report a rare pediatric observation of cutaneous nodule revealing an Anaplastic Large Cell Lymphoma (ALCL) ALK - cutaneous, muscular and ganglionic. It was classified according to who classification, treated by polychemotherapy with good outcome.


ALCL encompasses several distinct clinicopathologic entities with unique genomic under printing. This rare pediatric observation of ALCL presents a new discussion on a pathology still incompletely known.

Keywords: Anaplastic large cell lymphoma, Negative ALK, Child, Polychemotherapy, Ultrasound, Hematologic malignancies.