RESEARCH ARTICLE
Clustering of Cases of IDDM 2 to 4 Years after Hepatitis B Immunization is Consistent with Clustering after Infections and Progression to IDDM in Autoantibody Positive Individuals
John Barthelow Classen*
Article Information
Identifiers and Pagination:
Year: 2008Volume: 2
First Page: 1
Last Page: 6
Publisher Id: TOPEDJ-2-1
DOI: 10.2174/1874309900802010001
Article History:
Received Date: 25/11/2007Revision Received Date: 14/01/2007
Acceptance Date: 21/01/2007
Electronic publication date: 11/2/2008
Collection year: 2008
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Background:
Previous studies demonstrated clusters of cases of IDDM occurring 24 to 48 months after immunization with the hemophilus, pertussis and combined measles mumps rubella vaccines. Data was analyzed to determine if similar clustering of cases of IDDM occurred after immunization with the hepatitis B vaccine.
Methods:
Data on the incidence of IDDM from hepatitis B immunized and unimmunized cohorts of children was analyzed for the presence of clusters occurring after hepatitis B immunization.
Results:
Data from Italy, France, and New Zealand indicated rises in the incidence of IDDM occurred between 24 to 48 months after the introduction of the hepatitis B immunization in young children.
Conclusion:
Several different vaccines as well as infections with natural mumps virus are followed by clusters of cases of IDDM that occur about 24 to 48 months after immunization. This suggests a similar mechanism of action, possibly the triggering of a progressive autoimmune phenomenon.
