RESEARCH ARTICLE


Reversion to the Neurovilurent Genome Sequence of Polio Vaccine Virus Isolated from Community-Acquired Meningitis



Zenichiro Kato1, 2, 3, *, Yasushi Shimada4, Hiroaki Ishiko4, Naomi Kondo1, 2, 3
1 Department of Pediatrics, Graduate School of Medicine, Gifu University, Yanagido 1-1, Gifu 501-1194, Japan
2 Center for Emerging Infectious Diseases, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan
3 Center for Advanced Drug Research, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan
4 Research & Development Department, Mitsubishi Kagaku Bio-Clinical Laboratories, Inc., Tokyo, Japan

Article Information


Identifiers and Pagination:

Year: 2009
Volume: 3
First Page: 31
Last Page: 32
Publisher Id: TOPEDJ-3-31
DOI: 10.2174/1874309900903010031

Article History:

Received Date: 12/02/2009
Revision Received Date: 23/02/2009
Acceptance Date: 09/03/2009
Electronic publication date: 20/3/2009
Collection year: 2009

© 2009 Kato et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Pediatrics, Graduate School of Medicine, Gifu University, Yanagido 1-1, Gifu 501- 1194, Japan; Tel: +81-58-230-6386; Fax: +81-58-230-6387; E-mail: zen-k@gifu-u.ac.jp


Abstract

Neurologic complication associated with the use of live attenuated oral poliomyelitis vaccine is uncommon, but vaccine-associated paralytic poliomyelitis in recipients or contacts has sometimes been reported. We report here a community- acquired aseptic meningitis case and the genetic investigation of the isolated poliovirus type 2. The results of the genetic analysis indicate that the mechanism of this meningitis could be the result of the reversion of the virus during replication in the other vaccine recipients, suggesting a quest for revising the current vaccination program.

Keywords: Poliovirus, vaccine, meningitis, genetic reversion, neurovirulence.