Reversion to the Neurovilurent Genome Sequence of Polio Vaccine Virus Isolated from Community-Acquired Meningitis
Zenichiro Kato1, 2, 3, *, Yasushi Shimada4, Hiroaki Ishiko4, Naomi Kondo1, 2, 3
Identifiers and Pagination:Year: 2009
First Page: 31
Last Page: 32
Publisher Id: TOPEDJ-3-31
Article History:Received Date: 12/02/2009
Revision Received Date: 23/02/2009
Acceptance Date: 09/03/2009
Electronic publication date: 20/3/2009
Collection year: 2009
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Neurologic complication associated with the use of live attenuated oral poliomyelitis vaccine is uncommon, but vaccine-associated paralytic poliomyelitis in recipients or contacts has sometimes been reported. We report here a community- acquired aseptic meningitis case and the genetic investigation of the isolated poliovirus type 2. The results of the genetic analysis indicate that the mechanism of this meningitis could be the result of the reversion of the virus during replication in the other vaccine recipients, suggesting a quest for revising the current vaccination program.