Tobacco Smoke Exposure and Somatic Mutation in Newborns
Stephen G. Grant*
Identifiers and Pagination:Year: 2010
First Page: 10
Last Page: 13
Publisher Id: TOPEDJ-4-10
Article History:Received Date: 29/01/2010
Revision Received Date: 14/04/2010
Acceptance Date: 22/04/2010
Electronic publication date: 24/6/2010
Collection year: 2010
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Maternal exposure to tobacco smoke is known to have deleterious effects on the developing fetus, but it has only recently been shown that there may be life-long consequences due to genotoxic damage. Analysis of newborn cord bloods with the GPA somatic mutation assay demonstrates a significant effect of maternal active smoking and suggests that similar mutational induction occurs in mothers who experience only secondary exposure to environmental tobacco smoke (ETS). Moreover, in both cases, mutational induction occurs by the same molecular mechanism, likely chromosome missegregation, resulting in an effective loss of one parental chromosome 4 and duplication of the other. These data also suggest that quitting smoking during pregnancy without actively avoiding secondary ETS exposure is not effective at protecting the unborn child from the genotoxic effects of tobacco smoke.