RESEARCH ARTICLE
Septic Shock
John S. Giuliano Jr.*
Yale University School of
Medicine, 333 Cedar Street, P.O. Box 208064, New Haven, CT 06520-
8064, USA.
Article Information
Identifiers and Pagination:
Year: 2013Volume: 7
First Page: 28
Last Page: 34
Publisher Id: TOPEDJ-7-28
DOI: 10.2174/1874309901307010028
Article History:
Received Date: 17/12/2012Revision Received Date: 21/12/2012
Acceptance Date: 02/12/2013
Electronic publication date: 22/2/2013
Collection year: 2013
© 2013 John S. Giuliano Jr.
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Pediatric severe sepsis and septic shock continue to be significant causes of childhood morbidity and mortality worldwide. The following review will highlight some of the controversies surrounding the consensus definitions. It will chronicle recent clinical and translational research, focusing on pediatric sepsis-specific challenges investigators face. It will also address the pathophysiology of severe sepsis and septic shock, including up-to-date therapeutic recommendations.
Keywords: Pediatrics, children, PIRO, pathophysiology, therapy.
