Risk of Vaccine Induced Diabetes in Children with a Family History of Type 1 Diabetes
John Barthelow Classen*
Identifiers and Pagination:Year: 2008
First Page: 7
Last Page: 10
Publisher Id: TOPEDJ-2-7
Article History:Received Date: 25/11/2007
Revision Received Date: 15/01/2007
Acceptance Date: 21/01/2007
Electronic publication date: 13/2/2008
Collection year: 2008
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Cohort data from Denmark in all children born from January 1, 1990 to December 31, 2000 was analyzed to assess the association between immunization and type 1 diabetes in all Danish children and in a subgroup where children had a sibling with type 1 diabetes. Pediatric vaccines were associated with a statistically significant increased risk of type 1 diabetes in 12 of 21 endpoints in the general population. The rate ratios in children who received at least one dose of a specific vaccine were also elevated in the subgroup and were statistically the same as in the general population. Three doses of the hemophilus vaccine were associated with a rate ratio of 1.23 (1.02< RR<1.48) and an absolute risk in the general population of three cases/100,000 per year compared to 1.58 (0.60< RR<4.15) and an absolute risk of 2885 cases/100,000 per year in the subgroup with a sibling with type 1 diabetes. The hemophilus immunization is associated with a cumulative attributable risk of 2.3/100 (2.3%) in the subgroup.