Risk of Vaccine Induced Diabetes in Children with a Family History of Type 1 Diabetes

John Barthelow Classen*
Classen Immunotherapies Inc., 6517 Montrose Avenue, Baltimore, MD 21212, USA.

© 2008 John Barthelow Classen

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Classen Immunotherapies Inc., 6517 Montrose Avenue, Baltimore, MD 21212, USA;


Cohort data from Denmark in all children born from January 1, 1990 to December 31, 2000 was analyzed to assess the association between immunization and type 1 diabetes in all Danish children and in a subgroup where children had a sibling with type 1 diabetes. Pediatric vaccines were associated with a statistically significant increased risk of type 1 diabetes in 12 of 21 endpoints in the general population. The rate ratios in children who received at least one dose of a specific vaccine were also elevated in the subgroup and were statistically the same as in the general population. Three doses of the hemophilus vaccine were associated with a rate ratio of 1.23 (1.02< RR<1.48) and an absolute risk in the general population of three cases/100,000 per year compared to 1.58 (0.60< RR<4.15) and an absolute risk of 2885 cases/100,000 per year in the subgroup with a sibling with type 1 diabetes. The hemophilus immunization is associated with a cumulative attributable risk of 2.3/100 (2.3%) in the subgroup.

Keywords: Type 1 diabetes mellitus, vaccines, hemophilus, pertussis, polio.